Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in DED. ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study.

Allegro Ophthalmics announced positive results of an ex-US proof-of-concept clinical trial of the new investigational ALG-1007 topical drop drug candidate in patients with dry eye disease (DED). The results were presented by Eric D. Donnenfeld, MD, last week at the 2019 American Society of Cataract and Refractive Surgery and American Society of

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Alg-1007 allegro

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ALG-1007 is a topical treatment in development for potential use in patients with dry eye disease (DED), a condition affecting millions of people in the United States. ALG-1007 bolsters Allegro’s existing anti-integrin portfolio, which includes risuteganib (Luminate),currently being developed for diabetic macular edema (DME) and intermediate dry age-related macular degeneration (intermediate

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The other product, ALG-1007, is a topical integrin regulator that is currently being evaluated in dry eye syndrome (DES). While acquiring these two assets from Allegro will help Bausch Health to expand its current pipeline for ophthalmology indications,

“These early results suggest that ALG-1007 improves the signs and symptoms of dry eye, a disease that affects millions of people globally, with symptoms that include scratchy, stinging or burning sensations, and pain or redness in the eye. On Thursday, May 2, Allegro’s President and CEO Vicken Karageozian, M.D., will provide an overview on the company’s vision moving forward into other ocular indications at the Ophthalmology Innovation Summit (OIS). Then on Monday, May 6, Eric D. Donnenfeld, M.D., will present full study results of the ALG-1007 ex-U.S. proof-of-concept clinical trial for DED at ASCRS•ASOA.

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ALG-1007 demonstrated a strong signal in an ex-U.S. proof-of-concept clinical trial in which it showed a dose-response curve and that it was generally well-tolerated.

proof-of-concept clinical trial for the treatment of dry eye disease (DED) will be presented during the 37 th Congress of the Allegro’s other ophthalmology assets include ALG-1007, a topical integrin regulator under investigation for the treatment of dry eye disease, which is currently in phase 2 development outside the United States. ALG-1007 is a topical integrin regulator in development for potential use in patients with dry eye disease.
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ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study. For more information, visit www.allegroeye.com .

Phase 2 study. Expanding its anti-integrin portfolio, Allegro has developed ALG-1007, an anti-integrin drug candidate for topical use in dry eye disease. ALG-1007 has successfully completed an ex-U.S. proof-of-concept study in humans, and is currently being evaluated in a larger ex-U.S. Phase 2 study. ALG 1007, a peptide integrin inhibitor is being developed by Allegro Ophthalmics for the treatment of dry eye disease (DED). ALG 1007 inhibits the leucocyte ALG 1007 - AdisInsight ALG-1007 is a topical treatment in development for potential use in patients with dry eye disease (DED), a condition affecting millions of people in the United States.

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